Phage-loaded Injectable Hydrogel for Treating Bone and Implant Associated Infections
This patent-pending technology relates to antimicrobial therapeutics and tissue regeneration, specifically to a shear-thinning, phage-loaded injectable hydrogel for treating osteomyelitis. This hydrogel enables targeted phage delivery to combat bacterial infections while simultaneously promoting bone regeneration. Additionally, methods of fabrication and potential applications of this technology are described.
Bacterial Sensing Platform, Methods of Making and Uses
This patent-pending technology is a novel hydrogel-based biosensing platform capable of detecting pathogenic bacteria in water and urine samples. The sensor consists of polymer chains held together by pathogen-responsive DNA, forming a coloured gel that is visible to the naked eye. Bacteriophage-induced target amplification enhances sensor performance. It is designed to be compatible with on-site testing, allowing for consumer-level E. coli detection with a simple colour change.
Flushable, Biodegradable and Plant-Based Superabsorbent Fibrous Hydrogel for Menstrual Cups
This patent-pending technology pertains to a plant-based superabsorbent fibrous material designed to be inserted into menstrual cups to facilitate the removal process and address one of the primary barriers to menstrual cup adoption. Furthermore, the inclusion of these superabsorbent fibers enhances the cup’s ability to retain menstrual fluid, enabling cleaner and more convenient removal while encouraging consumers to choose menstrual cups for period management. This technology helps overcome the limitations of menstrual cups and reduces waste generation associated with other menstrual products, such as tampons and pads.
3D Hydrogel Microarrays for Highly Sensitive Immunofluorescence Detection
This patent-pending technology is composed of a biosensing interface comprised of 3D proteinaceous hydrogels in a microarray, embedded with biorecognition elements, capture antibodies (CAb), manufactured with a novel noncontact bioprinting fabrication process for high throughput scalability. The 3D microstructure of these hydrogels significantly increases the surface area available for biosensing while minimizing nonspecific binding and background noise for clinical diagnostics and monitoring applications.
Method of Comparison for NK Cell Phenotypes Using Microfluidic Droplets
This patent-pending technology utilizes a droplet-based microfluidic platform to encapsulate NK and cancer cells at various effector-to-target (E:T) ratios. It enables real-time, single-cell monitoring of NK cell phenotypes, comparing peripheral blood-derived and expanded NK cells under both standard media and tumor-mimicking ascitic fluid conditions. This innovation reveals critical differences in cytotoxic activity, killing time, and serial killing across phenotypes, overcoming limitations of traditional bulk assays. With potential applications in drug screening and personalized immunotherapy, this platform offers a precise, high-throughput solution to optimize NK cell-based cancer treatments.
A New Functional Nucleic Acid Probe for Food-borne Pathogen Salmonella typhimurium
This patent pending technology details an oligonucleotide-based probe that is capable of detecting Salmonella within complex matrices such as clinical samples and food. The probe has been employed within a cost-effective pipette tip-based sensor that allows for colorimetric reporting of Salmonella within an hour without the need for complex instruments.
Nanostructured Liquid-Infused Electrochemical Biosensor
This patent pending technology relates to creating an electrochemical biosensor by integrating a nanostructured conductive metal (gold) electrode and liquid-infused repellent coating to reduce fouling on the surface of electrodes. This Liquid Nano Electrodes (LNEs) are coated with bio recognition elements, in this case a double-stranded DNA probe specific to an Escherichia coli barcode. The LNEs promote selective target binding while repelling undesired species, and generate an electrochemical signal in a rapid one-pot assay that only takes an hour. The LNEs are effective in analyzing panels of clinical samples, distinguishing E. coli infected urine and blood culture samples from patient samples infected with other bacteria or non-infected.
Composition and Methods for Bacteriophage Susceptibility screening
This patent pending technology is an ultraportable, high throughput phage screening platform provided in a shelf-stable, ready-to-use, all-inclusive solid or gel format. This system eliminates the required stage-wise assays and increases the generated detectable signal by ~90%. Phage susceptibility screening can be completed in as low as 30 minutes, promising easier and cheaper transportation of this technology around the world and as a result, increased accessibility to therapeutic phage.
Food Packaging System for Detecting Pathogenic Bacteria
This patent pending technology is a novel in situ food contamination detection platform, capable of detecting pathogenic bacteria within sealed packaging. This system consists of an inclined packaging tray as well as a sensing interface which includes a reagent saturated membrane and bacterial sensor. It can be used with numerous food contaminants, sensors, and a variety of food products.
Turning Biomolecules into 3D Hierarchical Wrinkled Structures
This patent pending technology relates to a transformative method, free of heat and solvents, that allows for the preservation of micro and nanostructure biologics while inducing substrate wrinkling. Soft phage microarrays are printed, and subsequent substrate shrinking, induces 2D phage microarrays to fold into complex 3D flower-like structures, for pathogen detection.
Self-assembling Nanofibrous Viral Microgels as Sprayable Antimicrobials
This patent pending technology relates to a high-throughput method of synthesizing sprayable phage microgels comprising suspended phage microgels that are prepared as a sprayable fluid composition. The sprayable fluid composition can be applied to any surface and can be used for biocontrol or preventing the growth of microorganisms on food products or food contact environments.
A Repellent Spray- constituting of hierarchal wrinkled microparticles exhibiting superhydrophobic, superoleophobic, and anti-microbial features applicable on various substrates
This patent pending technology is an omniphobic and antimicrobial wrinkled microparticle comprised of: a polymeric core, a wrinkled shell covering at least a portion of the core, and one or more hydrophobic molecular layers with one or more nanoparticle layers attached to the shell. There is also an optionally sprayable composition comprising the microparticles with specific preparation of the microparticles for the present application.
Fluorine-Free Superhydrophobic Surfaces, Methods of Making and Uses Thereof
The patent pending technology relates to surface engineering, and in particular, to fluorine-free superhydrophobic surfaces as well as methods of making and uses.
Methods of Making Omniphobic Materials with Hierarchical Structures and Uses Thereof
This patent pending technology relates to the field of materials engineering. In particular, the methods of making omniphobic materials with hierarchical structures and uses thereof.
Lubricant-infused surface biosensing interface, methods of making and uses thereof
This patent pending technology is a method for fabricating a biofunctionalized surface on a substrate, wherein the substrate comprises hydroxyl groups on the surface to be biofunctionalized, the method comprising: covalently attaching organosilane groups to less than all of the hydroxyl groups on the surface of the substrate; covalently attaching one or more biospecies to the surface of the substrate; and applying a lubricant to the substrate, wherein the biospecies comprises a biorecognition element that detects a target analyte in a sample. A biofunctionalized surface made therefrom and use thereof, such as for biosensing applications, are also disclosed.
This patent pending technology includes omniphobic materials which are physically and chemically modified at their surface to create hierarchically structured materials with both nanoscale and microscale structures that provide the omniphobic properties. Methods of making such omniphobic surfaces with hierarchical structures and uses, including as flexible films that repel contaminants, are also disclosed in the application.
This patent pending technology involves bio-functional surfaces that have self-assembled monolayers of fluorine groups with “built-in” functional groups promote targeted cell and biomolecule binding to the surface while reducing non-specific binding. Further, this application also relates to methods for preparing functional biomolecules, viruses and cells that can be covalently immobilized to prepare bio-functional surfaces.
A patent technology using a technique for separating components of a microfluid, comprises a self-intersecting micro or nano-fluidic channel defining a cyclic path for circulating the fluid over a receiving surface of a fluid component separating member; and equipment for applying coordinated pressure to the channel at a plurality of pressure control areas along the cyclic path to circulate the fluid over the receiving surface, applying a pressure to encourage a desired transmission through the separating member, and a circulating pressure to remove surface obstructions on the separating member. The equipment preferably defines a peristaltic pump. Turbulent microfluidic flow appears to be produced.
This patent pending technology uses lubricant – infused molds, such as omniphobic lubricant – infused molds, in processes for fabricating molded objects such as microfluidics devices. Such processes can comprise coating a mold with a layer comprising a lubricant tethering group to obtain a tether – coated mold, depositing a lubricant on the tether – coated mold to obtain a lubricant infused mold (LIM), depositing a molded object precursor into the LIM and solidifying to obtain the molded object, and removing the molded object from the LIM.
This patent pending technology involves photo-catalytically active coatings, having improved photocatalytic activity, with methods for producing graphene-oxide/TiO2 materials and new applications based on the improved photoactivity of the materials. For example, the graphene-oxide/TiO2 can be used in enhanced self-cleaning coatings for surfaces including cement, metal, glass, and wood. Furthermore, methods of producing functionalized graphene oxide-TiO2 materials and methods of coatings by surface modification of a substrate and functionalization of the functionalized graphene oxide-TiO2, the functionalized composite being coated onto the target surface after proper surface treatment.
Omniphobic Lubricant-Infused Surfaces for Improved Surface Smoothness
This patent pending technology involves a fabrication process where an omniphobic liquid-infused surface (OLIS) is used to manufacture smoother topographical surfaces. This process can be used when casting a liquid material (either molten or in solution) onto a solid substrate containing a rough surface. A liquid lubricant is placed onto the mold, covering the roughness of the solid mold and acts as a smooth interface between the mold and the foreign liquid material. Upon hardening of liquid material by a physical change or a chemical reaction, the solid material exhibits smoother surface topography, in comparison to that of the original mold. This manufacturing process can be adopted in inject molding of plastics and polymers, or the casting of metals, or ceramics, where the master mold has been fabricated with pores or roughness due to their fabrication processe
This patent pending technology involves articles, methods of making, and uses for modifying surfaces for simultaneously providing repellency and selective binding of desired moieties are disclosed. The repellant surfaces comprise a substrate and a lubricating layer immobilized over the substrate surface having a lubricating liquid having an affinity with the substrate. The substrate and the lubricating liquid are attracted to each other together by non-covalent attractive forces. The repellent surface further includes a binding group extending over the surface of the lubricating layer and the binding group has an affinity with a target moiety. The lubricating layer and the substrate form a slippery or repellent Surface configured and arranged for contact with a material that is immiscible with the lubricating liquid and the immiscible material contains the target moiety.
Producing silanized bio-species and one step rapid top down selective surface immobilization
This patent pending technology describes biofunctional surfaces that have self-assembled monolayers of fluorine groups with “built-in” functional groups promote targeted cell and biomolecule binding to the surface while reducing non-specific binding. Further, methods for preparing functional biomolecules, viruses and cells that can be covalently immobilized to prepare biofunctional surfaces are outlined.